7+ min ago   (55+ words) Pembrolizumab, one of the most widely prescribed cancer immunotherapies in the world, has long been dosed on the assumption that saturating the PD-1 receptor on T cells is the key to unlocking the immune system against tumours. A new translational…...

14+ min ago   (120+ words) Adoptive T cell therapy has delivered striking remissions in some blood cancers, but its promise in solid tumors has been repeatedly undermined by a stubborn problem: the therapeutic cells do not last. Engineered T cells that flood a tumor and…...

18+ min ago   (704+ words) Cardiovascular medicine is quietly undergoing a structural rethink, and the change begins with the order of operations....

47+ min ago   (101+ words) Higher income has long been treated as a reliable shield against chronic disease, but a sweeping new analysis of female breast cancer survivors in the United States suggests that this protection is anything but uniform. Drawing on four years of…...

1+ hour, 5+ min ago   (55+ words) Immunotherapy has transformed the outlook for people with advanced bladder and kidney cancer. Drugs known as immune checkpoint inhibitors, which block molecular brakes such as CTLA-4, PD-1 and PD-L1 to unleash the immune system against tumours, have dramatically improved long-term…...

1+ hour, 26+ min ago   (53+ words) Triple-negative breast cancer is the form of the disease that clinicians fear most. Lacking the three molecular targets — the estrogen receptor, the progesterone receptor and the HER2 protein — that anchor modern targeted therapies, it leaves patients with fewer options and a…...

1+ hour, 43+ min ago   (55+ words) Immune checkpoint inhibitors have rewritten the outlook for some patients with gastrointestinal cancers, turning once uniformly fatal diagnoses into manageable chronic conditions for a fortunate minority. Yet for every dramatic response there are many more patients whose tumours barely flinch,…...

1+ hour, 52+ min ago   (75+ words) Gastric cancer continues to rank among the most lethal malignancies worldwide, and a new study published in Medical Oncology has identified a molecular culprit that may explain how tumors in the stomach not only grow aggressively but also dismantle the…...

1+ hour, 52+ min ago   (651+ words) Patients with extensive-stage small cell lung cancer, one of the most difficult malignancies to treat once first-line therapy fails, may soon have a more convenient way to receive an immunotherapy that has already changed the treatment landscape....

1+ hour, 52+ min ago   (539+ words) A mitochondrial enzyme long known simply as a workhorse of cellular energy production has been revealed as a powerful suppressor of colorectal cancer, one of the most common and deadly malignancies worldwide....